Position Title: ASSISTANT RESEARCH PROFESSOR
Education/Training
TAMIL NADU AGRICULTURAL UNIVERSITY,
INDIA
B.V.SC.* 1975-80 VET. &
ANIMAL SCIENCEVETERINARY (MADRAS
COLLEGE)
*Equivalent toD.V.M. degree
TAMIL NADU AGRICULTURAL UNIVERSITY,
INDIA
M.V.SC. 1982-84 ANIMAL BREEDING
&
(MADRAS VETERINARY COLLEGE)
GENETICS
UNIVERSITY OF BRITISH COLUMBIA, VANCOUVER, BC, PH.D.
1991-96 ANIMAL
SCIENCE
CANADA
(REPRODUCTION)
Research/Professional Experience:
1) 09/08-present Assistant Research Professor, Washington State
University, Pullman, WA, USA
2) 12/01-08/08 Research Fellow, Res. Investigator, Res. Associate
University of Michigan, Ann Arbor, MI, USA
3) 01/00-11/01 Associate Scientist Kansas State University
Manhattan, KS, USA
4) 06/96-12/99 Postdoctoral Research Associate University of
Missouri-Columbia, USA
5) 09/93-05/96 UBC Graduate Research Fellow University of British
Columbia, Canada
6) 09/92-09/94 Graduate Teaching Assistant (Physiology), Univ. of
British Columbia, Canada
7) 09/91-08/92 Graduate Research Assistant (NSERC), University of
British Columbia, Canada
8) 01/91-08/91 Assistant Professor (Bull Semen Bank) T.N.
Agricultural University, India
9) 02/85-12/90 Assistant Professor (Abortion in Cattle) T. N.
Agricultural University, India
10) 01/82-11/82 Extension Officer (Animal Husbandry) Tamil Nadu,
India
11) 04/81-09/81 Veterinary Assistant Surgeon Tamil Nadu, India
Publications:
(28) Manikkam M, Thompson RC, Herkimer C, Welch KB, Flak J, Karsch
FJ, Padmanabhan V. 2008
Developmental Programming: Impact of Prenatal Testosterone Excess
on Pre- and Postnatal Gonadotropin
Regulation in Sheep. Biol Reprod 78:648-660.
(27) Steckler T, Manikkam M, Inskeep EK, Padmanabhan V. 2007
Developmental Programming: Follicular
persistence in prenatal testosterone-treated sheep is not
programmed by androgenic actions of testosterone.
Endocrinology 148:3532-3540
(26) Padmanabhan V, Manikkam M, Recabarren S, Foster D 2006
Prenatal testosterone excess programs
reproductive and metabolic dysfunction in the female Mol Cell
Endocrinol 246:165-174
(25) Manikkam M, Steckler TL, Welch KB, Inskeep EK, Padmanabhan V.
2006 Fetal Programming: Prenatal
Testosterone Treatment Leads to Follicular Persistence / Luteal
Defects. Partial Restoration of Ovarian
Function by Cyclic Progesterone Treatment. Endocrinology.
147:1997-2007
(24) Sarma HN, Manikkam M, Herkimer C, Dell'Orco J, Welch KB,
Foster DL, Padmanabhan V. 2005 Fetal
programming: excess prenatal testosterone reduces postnatal
luteinizing hormone, but not follicle-stimulating
hormone responsiveness, to estradiol negative feedback in the
female. Endocrinology 146:4281-91.
(23) Hampton JH, Manikkam M, Lubahn DB, Smith MF, Garverick HA 2004
Androgen receptor mRNA
expression in the bovine ovary Dom Anim Endocrinol 27:81-88
(22) Manikkam M, Crespi E, Doop D, Herkimer C, Lee JS, Yu S, Brown
MB, Foster DL, Padmanabhan V 2004
Fetal Programming: Prenatal Testosterone Excess Leads to Fetal
Growth Retardation and Postnatal Catch-up
Growth in Sheep Endocrinology 145:790-798.
(21) Manikkam, M., Li, Y., Mitchell, B. M., Mason, D. E., Freeman,
L. C. (2002). Potassium Channel
Antagonists Influence Porcine Granulosa Cell Proliferation,
Differentiation, and Apoptosis. Biol Reprod 67: 88-
98
(20) Manikkam, M., Bao, B., Rosenfeld, C.S., Yuan, X., Salfen,
B.E., Calder, M.D., Youngquist, R.S., Keisler,
D.H., Lubahn, D.B., Garverick, H.A. 2001. Expression of the bovine
estrogen receptor-β (BER-β) messenger
ribonucleic acid (mRNA) during the first ovarian follicular wave
and lack of change in the expression of BER-β
mRNA of second wave follicles after luteinizing hormone infusion
into cows. Anim. Reprod. Sci. 67:159-169.
(19) Manikkam, M., Calder, M.D., Salfen, B.E., Youngquist, R.S.,
Keisler, D.H., Garverick, H.A. 2001.
Concentrations of steroids and gene expression of steroidogenic
enzymes and gonadotropin receptors in
bovine ovarian follicles of first and second waves and changes in
second wave follicles after pulsatile LH
PHS 398/2590 (Rev. 05/01) Page ____6___ Biographical Sketch Format
Page +
infusion. Anim. Reprod. Sci. 67:189-203.
(18) Calder, M.D., Manikkam, M., Salfen, B.S., Youngquist, R.S.,
Lubahn, D.B., Lamberson W.R., Garverick,
H.A. 2001. Dominant Bovine Ovarian Follicular Cysts Express
Increased Levels of Messenger RNAs for
Luteinizing Hormone Receptor and 3β-Hydroxysteroid
Dehydrogenase Δ4Δ5 Isomerase Compared to Normal
Dominant Follicles. Biol. Reprod. 65:471-476.
(17). Garbayo, J.M., Green, J.A., Manikkam, M., Beckers,
J-F.,Kiesling, D.O., Ealy, A.D., Roberts, R.M. 2000.
Caprine pregnancy assoociated glycoproteins (PAG): Their cloning,
expression and Evolutionary Relationship
to other PAG. Mol. Reprod. Dev. 57:311-322.
(16). Rosenfeld CS, Yuan X, Manikkam M, Calder MD, Garverick HA,
Lubahn DB. 1999. Cloning, Sequencing,
and Localization of Bovine Estrogen Receptor-ß within the
Ovarian Follicle. Biol Reprod. 60: 691-697.
(15). Manikkam, M. and Rajamahendran, R. 1997. Progesterone-induced
Atresia of the Proestrus Dominant
Follicle in the Bovine Ovary: Changes in Diameter, the Insulin-like
Growth Factor System, Aromatase Activity,
Steroid Hormones and Apoptotic Index. Biol. Reprod. 57:580-587.
(14). Manikkam, M., Rajamahendran, R. and Rawlings, N.C. 1996.
Effect of bovine follicular fluid
administration during or after norgestomet treatment on the fate of
the proestrus dominant follicle in heifers.
Anim. Reprod. Sci. 44:149-163.
(13). Manikkam, M., Rajamahendran, R. and Rawlings, N.C. 1995.
Effects of bovine follicular fluid and
luteinizing hormone releasing hormone antagonist on the dominant
follicle maintained by a Norgestomet ear
implant in heifers. Can. J. Anim. Sci. 75:71-78.
(12). Rajamahendran, R. and Manikkam, M. 1994. Effects of exogenous
steroid hormones on the dominant
follicle maintained by a Norgestomet implant in heifers. Can. J.
Anim. Sci. 74:457-464.
(11). Taylor, C., Manikkam, M. and Rajamahendran, R. 1994. Changes
in ovarian follicular dynamics and
luteinizing hormone profiles following different progestagen
treatments in cattle. Can. J. Anim. Sci. 74:273-
279. Previous name used: Mohan M
(10). Manickam, R., Mohan, M., Sadasivam Pillai, K.G., Krishnamurti
C.R. 1990. Observations on nonsurgical
recovery and transfer of embryos in crossbred cows. Indian J. Anim.
Repr. 11: 121-124.
(9). Manickam, R., Mohan, M., Ramalingam, G. 1989. Studies on in
vitro drug sensitivity of isolates from
infertile cattle. Indian J. Vet. Med. 8:127-13 1.
(8). Mohan, M., Singh, B.K., Manickam, R. 1989. Seroepidemiological
studies on infectious bovine
rhinotracheitis (IBR) infection in bulls. Indian Vet. J. 66:
914-916.
(7). Balagopal, R., Mohan, M. and Manickam, R. 1989. A case report
on a monster with developmental
anomalies in a Tellicherry goat. Indian Vet. J. 66:179.
(6). Manickam R. Mohan M.1987. Seroepidemiological studies on
infectious bovine rhinotracheitis (IBR) viral
abortion in cows. Indian J. Anim. Sci. 57 (9):959-961.
(5). Manickam, R. and Mohan, M. 1987. Epidemiological studies on
Brucella abortus infection in milch cattle.
Indian Vet. J. 64:546-549.
(4). Manickam, R. and Mohan, M. 1987. A note on the outbreak of
Swinepox in Large White Yorkshire piglets.
Indian J. Vet. Med. 7:71-72.
(3). Mohan, M., Ulaganathan, V., Rodricks, I.M., Bhuvanakumar, C.K.
and Iyue, M. 1986. Reproduction rate
and viability of Merino, Nilagiri and halfbred Merino. II. Age
specific replacement rate, and net reproduction
rate. Trop. Anim. Health Prod. (UK) 18:177-183.
(2). Mohan, M., Ulaganathan, V., Rodricks, I.M., Bhuvanakumar, C.K.
and lyue, M. 1986. Reproduction rate
and viability of Merino, Nilagiri and halfbred Merino. I.
Fertility, prolificacy and viability. Trop. Anim. Health
Prod. (UK) 18:171-176.
(1). Mohan, M. and Ulaganathan, V. 1986. Repeatability of
reproduction rate in Merino, Nilagiri and their
crosses. Indian Vet. J. 63:222-226.