Skinner Laboratory

Publications

2014

Carlos Guerrero-Bosagna, and Michael K. Skinner (2014) Environmental Epigenetics and Phytoestrogen/Phytochemical Exposures. JSBMB 139:270– 276.

Michael K. Skinner, Marina Savenkova, Bin Zhang, David Crews (2014) Gene Bionetworks Involved in the Epigenetic Transgenerational Inheritance of Altered Mate Preference:  Environmental Epigenetics and Evolutionary Biology. (Submitted).

Michael K. Skinner, Carlos Gurerrero-Bosagna, Md. Haque, Sarah Knutie, Jennifer Koop, Dale Clayton (2014) Role of Epigenetics in Speciation and Evolution of Darwin’s Finches.  (Submitted).

Ross Gillette, Isaac Miller-Crews, Eric E. Nilsson, Michael K. Skinner, Andrea C. Gore, David Crews (2014) Ancestral exposure to endocrine disrupting chemical modifies stress reactivity in males and females (Submitted).

Jianqiang Bao, Ying Zhang, Andrew S. Schuster, Nicole Ortogero, Eric E. Nilsson, Michael K. Skinner, Wei Yan (2014) Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice. Cell Death and Differentiation (In Press).

Michael K. Skinner (2014) Environmentally Induced Epigenetic Transgenerational Inheritance:  Ancestral Ghosts in your Genome. Scientific American (Submitted).

Eric Nilsson and Michael K. Skinner (2014) Definition of Epigenetic Transgenerational Inheritance and Biological Impacts. Editor: Trygve Tollefsbol. Elsevier Publisher (In Press).

Amanda Feeney, Eric Nilsson and Michael K. Skinner (2014) Cytokine (IL16) and Tyrphostin Actions on Ovarian Primordial Follicle Development. Reproduction (Submitted).

Michael K. Skinner and Carlos Guerrero-Bosagna (2014) Role of CpG Deserts in the Epigenetic Transgenerational Inheritance of Differential DNA Methylation Regions. Current Opinion in Genetics & Development. (Submitted).

Carlos Guerrero-Bosagna, Shelby Weeks and Michael K. Skinner (2014) Identification of Genomic Features in Environmentally Induced Epigenetic Transgenerational Inherited Sperm Epimutations. PLoS ONE (Submitted).

Md. Muksitul Haque, Michael K. Skinner and Lawrence B. Holder (2014) Imbalanced Class Problem in Epigenetics. J Comp Biol (Submitted).

Michael K. Skinner (2014) Environmentally Induced Epigenetic Transgenerational Inheritance:  Ancestral Ghosts in your Genome. Scientific American (Submitted).

Eric Nilsson, Ginger Larsen and Michael K. Skinner (2014) Roles of Gremlin1 and Gremlin2 in Regulating Ovarian Primordial to Primary Follicle Transition. (Submitted).

William P. Kabasenche, and Michael K. Skinner (2014) DDT, Epigenetic Harm, and Transgenerational Environmental Justice. (Submitted).

Eric Nilsson and Michael K. Skinner (2014) Environmentally Induced Epigenetic Transgenerational Inheritance of Disease Susceptibility. Translational Research (In Press).

Wioletta Czaja, Karen Y. Miller, Bruce L. Miller, and Michael K. Skinner (2014) Structural and functional conservation of fungal MatA and human SRY sex determining proteins. Nature (Submitted).

Mohan Manikkam, M. Muksitul Haque, Carlos Guerrero-Bosagna, Eric E. Nilsson, Michael K. Skinner (2014) Pesticide methoxychlor promotes the epigenetic transgenerational inheritance of adult onset disease and sperm epimutations through the female germline. (In Prep).

2013

Michael K. Skinner, Mohan Manikkam, Rebecca Tracey, Eric Nilsson, Md. M. Haque and Carlos Guerrero-Bosagna (2013) Ancestral dichlorodiphenyltrichlorethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity. BMC Medicine 11:228.

Michael K. Skinner (2013) Environmentally Induced Epigenetic Transgenerational Inheritance of Disease. In Ten Critical Topics in Reproductive Medicine, S. Sanders, Ed. (Science/AAAS, Washington, DC), pp. 18-20.

Guerrero-Bosagna C, Skinner MK. (2013) Environmental epigenetics and effects on male fertility. Adv Exp Med Biol. 2014;791:67-81.

Hope BT, Skinner MK, Kenny PJ, Akbarian S. (2013) Exploring the epigenetics of cocaine resistance. Nat Med. 19(2):136-7.

Carlos Guerrero-Bosagna, Marina Savenkova, Md. M. Haque, Ingrid Sadler-Riggleman, and Michael K. Skinner (2013) Environmentally Induced Epigenetic Transgenerational Inheritance of Altered Sertoli Cell Transcriptome and Epigenome: Molecular Etiology of Male Infertility. PLoS ONE 8(3):e59922.

Michael K. Skinner, Carlos Guerrero-Bosagna, Md. M. Haque, Eric Nilsson, Ramji Bhandari and John McCarrey (2013) Environmentally Induced Transgenerational Epigenetic Reprogramming of Primordial Germ Cellls and Subsequent Germline. PLoS ONE 15;8(7)e66318.

Eric Nilsson, Bin Zhang and Michael K Skinner (2013) Gene Bionetworks that Regulate Ovarian Primordial Follicle Assembly. BMC Genomics 14:496.

Md. Muksitul Haque, Lawrence B. Holder, Michael K. Skinner, Diane J. Cook (2013) Generalized Query Based Active Learning to Identify Differentially Methylated Regions in DNA.  IEEE/ACM Trans Comput Biol Bioinform 10(3)632-44.

Michael K. Skinner (2013) Environmental Epigenetics and Epigenetic Transgenerational Inheritance.  Environmental Epigenomics in Health and Disease. Epigenetics and Human Health, pp 245-256. Springer Berlin Heidelberg. Editors: Randy L Jirtle, Frederick L. Tyson.

Rebecca Tracey, Mohan Manikkam, Carlos Guerrero-Bosagna, & Michael K. Skinner (2013) Hydrocarbon (Jet Fuel JP-8) Induces Epigenetic Transgenerational Inheritance of Adult-Onset Disease and Sperm Epimutations.  Reproductive Toxicology 36:104-116.


Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna & Michael K. Skinner (2013) Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Adult-Onset Disease and Sperm Epimutations. PLoS ONE 8(1):e55387.

 

 

2012

Skinner MK, Manikkam M, Haque Md., Zhang B, Savenkova M (2012) Epigenetic Transgenerational Inheritance of Somatic Transcriptomes and Epigenetic Control Regions. Genome Biology 3:13(10):R91.

Carlos Guerrero-Bosagna, Trevor R. Covert, Matthew Settles, Matthew D. Anway, and Michael K. Skinner. (2012) Epigenetic Transgenerational Inheritance of Vinclozolin Induced Mouse Adult Onset Disease and Associated Sperm Epigenome Biomarkers.  Reprod Toxicol 34(4):694-707.

Eric Nilsson, Ginger Larsen, Mohan Manikkam, Carlos Guerrero-Bosagna and Michael K. Skinner (2012) Environmental Toxicants Induce Epigenetic Transgenerational Inheritance of Ovarian Disease. PLoS One. 7(5):e36129.

Mohan Manikkam, Carlos Guerrero-Bosagna, Rebecca Tracey, Md. M. Haque and Michael K. Skinner (2012) Transgenerational Actions of Environmental Compounds on Reproductive Disease and Identification of Epigenetic Biomarkers of Ancestral Exposures. PLoS ONE  7(2):e31901.


Bhandari R, Haque Md, Skinner MK (2012) Global Genome Analysis of the Downstream Binding Targets of Testis Determining Factor SRY and SOX9. PLoS One. 7(9):e43380.


Bhandari R, Schinke E, Haque Md, Skinner MK (2012) SRY Induced TCF21 Genome-wide Targets and Cascade of bHLH Factors During Sertoli Cell Differentiation and Male Sex Determination in Rats. Biol Reprod 6:87(6):131.


Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna, Michael K. Skinner (2012) Pesticide and Insect Repellent Mixture (Permethrin and DEET) Induces Epigenetic Transgenerational Inheritance of Disease and Sperm Epimutations.  Reprod Toxicol 34(4):708-19.

Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna, and Michael K. Skinner (2012) Dioxin (TCDD) Induces Epigenetic Transgenerational Inheritance of Adult Onset Disease and Sperm Epimutations. PLoS One. 7(9):e46249.

Crews D, Gillette R, Manikkam M, Savenkova M and Skinner MK (2011) Epigenetic Transgenerational Alterations to Stress Responses. PNAS 5;109(23):9143-8.

Guerrero-Bosagna C and Skinner MK (2011) Environmentally Induced Epigenetic Transgenerational Inheritance of Phenotype and Disease. Molecular and Cellular Endocrinology  6;354(1-2):3-8.

2011

Michael K Skinner (2011) Role of Epigenetics in Developmental Biology and Transgenerational Inheritance Birth Defects Research Embryo Today 93(1):51-5.

Skinner MK, Manikkam M, Guerrero-Bosagna C. (2011) Epigenetic transgenerational actions of endocrine disruptors. Reprod Toxicol. 31(3):337-43.

Michael K. Skinner (2011) Environmental Epigenomics and Disease Susceptibility.  EMBO Rep. 2011 Jul 1;12(7):620-2.

Nilsson EE, Schindler R, Savenkova MI and Skinner MK (2011) Inhibitory Actions of Anti-Müllerian Hormone (AMH) on Ovarian Primordial Follicle Assembly. PLoS One. 2011;6(5):e20087.

Bhandari R, Sadler-Riggleman I, Clement T and Skinner MK (2011) Basic Helix-Loop-Helix Transcription Factor TCF21 is a Downstream Target of the Male Sex Determining Gene SRY. PLoS One. 2011;6(5):e19935.

Michael K. Skinner (2011) Environmental Epigenetic Transgenerational Inheritance and Somatic Epigenetic Mitotic Stability. Epigenetics 1;6(7):838-42.

Clement T, Bhandari R, Sadler-Riggleman I, Skinner MK (2011) Sry directly regulates the neurotrophin-3 promoter during male sex determination and testis development. Biology of Reproduction 85, 277–284.

 

2010

Skinner MK, Manikkam M, Guerrero-Bosagna C. (2010) Epigenetic transgenerational actions of environmental factors in disease etiology. Trends Endocrinol Metab. 21(4):214-22.

Z. Hochberg, C Junien, J-C Carel, P Boileau, C Deal, R Feil, M Fraga, M Constancia, Y Le Bouc, K Lillycrop, R Scharfmann, A Sheppard, M Skinner, M Szyf, R Waterland, DJ Waxman, E Whitelaw, K Ong, K Albertsson-Wikland (2011) Child health, developmental plasticity, epigenetics and programming.  Endocr Rev. 32(2):159-224. 

Clement T, Savenkova M, Settles M, Anway M and Skinner MK (2010) Alteration of the developing testis transcriptome following embryonic vinclozolin exposure.  Reprod Toxicol.30(3):353-64.

Nilsson EE, Savenkova MI, Schindler R, Zhang B, Schadt EE and Skinner MK (2010) Gene bionetwork analysis of ovarian primordial follicle development. PLoS One. Jul 16;5(7).

Guerrero-Bosagna C, Settles M, Lucker BJ and Skinner MK (2010) Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome. PLoS One. Sep 30;5(9).

C. Guerrero-Bosagna & M.K. Skinner (2010) Transgenerational epigenetic actions of environmental compounds.  Animal Reproduction. 7(3): 165-167.

Schindler R, Nilsson E, Skinner MK. (2010) Induction of ovarian primordial follicle assembly by connective tissue growth factor CTGF.  PLoS One. Sep 24;5(9).

Michael K Skinner (2010) Metabolic Disorders: Fathers’ nutritional legacy. Nature. 2010 Oct 21;467(7318):922-3.

Michael K. Skinner (2010) Epigenetic Transgenerational Toxicology.  Comprehensive Toxicology, Chapter 12.07.  Elsevier 2010.

2009

Hahn KL, Beres BJ, Rowton MJ, Skinner MK, Chang Y, Rawls A, and J Wilson-Rawls (2009) A deficiency of lunatic fringe is associated with cystic dilation of the rete testis. Reproduction. 137(1):79-93.

Nilsson EE and Skinner MK (2009) Progesterone Regulation of Primordial Follicle Assembly in Bovine Fetal Ovaries. Molecular and Cellular Endocrinology  313  9–16. 

Nilsson EE, Dole G and Skinner MK (2009) Neurotrophin NT-3 Promotes Ovarian Primordial to Primary Follicle Transition. Reproduction.  138(4):697-707.

Guerrero-Bosagna C, Skinner MK (2009) Epigenetic Transgenerational Effects of Endocrine Disruptors on Male Reproduction.  Seminars in Reproductive Medicine 27(5):403-8.

Skinner MK, Guerrero-Bosagna C (2009) Environmental signals and transgenerational epigenetics.  Epigenomics 1(1), 111–117.

Michael K. Skinner, Eric E. Nilsson and Ramji K. Bhandari (2009) Cell-cell signaling in the testis and ovary.  In Ralph A. Bradshaw and Edward A. Dennis, editors: Handbook of Cell Signaling 2nd edition, Oxford: Academic Press, 2009, pp. 2663-2678.

2008

Anway MD and Skinner MK (2008) Epigenetic Programming of the Germ Line: Effects of Endocrine Disruptors on the Development of Transgenerational Disease. Reproductive Biomedicine Online. 16:23-25.

Anway MD and Skinner MK (2008) Transgenerational effects of the endocrine disruptor vinclozolin on the prostate transcriptome and adult onset disease. Prostate. 1;68(5):517-29.

Westfall S, Nilsson EE and MK Skinner (2008) Role of triptolide as an adjunct chemotherapy for ovarian cancer. Chemotherapy 54:67-76.

Anway MD, Rekow SS, and MK Skinner (2008) Transgenerational epigenetic programming of the testis transcriptome.  Genomics 91:30-40

Dole G, Nilsson EE and Skinner MK (2008)  Glial-derived neurotrophic factor promotes ovarian primordial follicle development and cell-cell interactions during folliculogenesis.  Reproduction 135:671-682

Muir T, Wilson-Rawls J, Stevens JD, Rawls A, Schweitzer R, Kang C and Skinner MK (2008)  Integration of CREB and bHLH transcriptional signaling pathways through direct heterodimerization of the protiens:  Role in muscle and testis development.  Molecular Reproduction and Development 75(11):1637-52

Ye X, Skinner MK, Kennedy G and Chun J (2008)  Age-dependant loss of sperm production in mice via impaired lysophosphatidic acid signaling.  Biology of Reproduction 79, 328-336

Nilsson EE, Anway MD, Stanfield J, Skinner MK.(2008) Transgenerational epigenetic effects of the endocrine disruptor vinclozolin on pregnancies and female adult onset disease.Reproduction.135(5):713-21.

Stevens JD, Roalson EH, Skinner MK.  (2008) Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.Differentiation.  76(9):1006-22.

Anway MD, Rekow SS, Skinner MK. (2008) Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis. Reprod Toxicol. 26(2):100-6.

Memon MA, Anway MD, Covert TR, Uzumcu M, Skinner MK. (2008) Transforming growth factor beta (TGFbeta1, TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal development.Mol Cell Endocrinol. 6;294(1-2):70-80.

Skinner MK, Schmidt M, Savenkova MI, Sadler-Riggleman I, Nilsson EE. (2008) Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle development. Mol Reprod Dev. 75(9):1457-72.

Skinner MK, Anway MD, Savenkova M, Gore A, Crews D, (2008) Transgeneratioanl epigenetic programming of the brain transcriptome and anxiety behavior: environment-genome interactions.  PlosOne 2008;3(11):e3745.

2007

Nilsson EE, Rogers N and MK Skinner (2007) Actions of the anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition.  Reproduction 134:209-221. 

Jirtle RL and MK Skinner (2007) Environmental Epigenomics and Disease Susceptibility.  Nature Genetics Rev. 8:253-262.

Clement TM, Anway MD, Uzumcu M and MK Skinner.  (2007) Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: candidate regulatory genes. Reproduction 134:455-472.

Skinner MK (2007) What is an epigenetic transgenerational phenotype? F3 or F2. Reproductive Toxicology. 25:2-6

Skinner MK (2007) Epigenetic Transgenerational Toxicology and Germ Cell Disease.  International Journal of Andrology.  30:393-397.

Skinner MK (2007) Endocrine Disruptors and Epigenetic Transgenerational Disease Etiology.  Pediatric Research  61:48R-50R.

Crews D, Gore AC, Hsu TS, Dangleben NL, Spinetta M, Schallert T, Anway MD and Skinner MK (2007) Transgenerational epigenetic imprints on mate preference. Proc Natl Acad Sci 104:5942-5946.

Skinner MK and Anway MD (2007) Epigenetic Transgenerational Actions of Vinclozolin on the Development of Disease and Cancer. Critical Reviews in Oncogenesis 13(1):75-82.

2006

Anway MD, Memon M, Uzumcu M, and MK Skinner (2006) Transgenerational effect of the endocrine disruptor vinclozolin on male spermatogenesis.  Journal of Andrology 27:868-879.

Skinner MK and Anway MD (2006) Seminiferous cord formation and germ cell programming: epigenetic transgenerational actions of endocrine disruptors.  Annals New York Academy of Science 1061:18-32.

 Anway MD, Leathers C and MK Skinner (2006) Endocrine disruptor vinclozolin induced epigenetic transgenerataional adult onset disease.  Endocrinology 147:5515-5523.

Nilsson EE, Stanfield J, and MK Skinner (2006) Interactions between progesterone and tumor necrosis factor-alpha in the regulation of primordial follicle assembly.  Reproduction 132:877-886.

Nilsson EE, Detzel C, and MK Skinner (2006) Platelet-derived growth factor modulates the primordial to primary follicle transition.  Reproduction 131:1007-1015.

Skinner MK (2006) Epigenetic transgenerational actions of endocrine disruptors through the male germ-line. In: Male-Mediated Development Toxicology.  Ed. D. Anderson and MH Brinkworth, Royal Society of Chemistry, Cambridge, UK, CH001, pp. 1-4 

Anway, MD and MK Skinner (2006) Epigenetic Transgenerational Actions of Endocrine Disruptors.  Endocrinology 147:S43-S49.

Chang HS, Anway MD, Rekow SS, and Skinner MK (2006) Transgenerational epigenetic imprinting of the male germ-line by endocrine disruptor exposure during gonadal sex determination. Endocrinology 147:5524-5541(Article Retracted June 2009).

2005

Ye X, Hama K, Contos J, Anliker B, Inoue A, Skinner MK, Suzuki H, Amano T, Kennedy G, Arai H, Aoki J and Chun J. (2005) LPA3-mediated lysophosphatidic acid signaling in embryo implantation and spacing. Nature 435:104-108.

Anway M, Cupp AS, Uzumcu M and MK Skinner (2005) Epigenetic transgenerational actions of endocrine disruptors on male fertility. Science 308:1466-1469.

Meachem SJ, Ruwanpura SM, Ziolkowski J, Ague J, Skinner MK and KL Loveland.  (2005) Developmentally distinct in vivo effects of FSH on proliferation and apoptosis during testis maturation.  Journal of Endocrinology 186:429-446.

Muir T, Sadler-Riggleman I, Stevens JD, and MK Skinner (2005) Role of the basic helix-loop-helix protein ITF2 in the hormonal regulation of Sertoli Cell Differentiation.  Molecular Reproduction and Development 73:491-500.

Muir T, Sadler-Riggleman I, and MK Skinner (2005) Role of the basic helix-loop-helix transcription factor, scleraxis, in the regulation of Sertoli cell function and differentiation.  Molecular Endocrinology.19:2164-2174.

Westfall S, and MK Skinner (2005) Inhibition of Phosphatidylinositol 3-Kinase Sensitizes Ovarian Cancer Cells to Carboplatin and Allows Adjunct Chemotherapy Treatment.  Molecular Cancer Therapeutics 4:1764-1771.

Kezele P, Nilsson EE and MK Skinner (2005) Keratinocyte growth factor acts as a mesenchymal factor that promotes ovarian primordial to primary follicle transition.  Biology of Reproduction 73:967-973.

Skinner MK. (2005) Regulation of primordial follicle assembly and development.  Hum Reprod Update. 11:461-71.

Chaudhary J, Sadler-Riggleman I, Ague JM, and MK Skinner (2005) The helix-loop-helix inhibitor of differentiation (Id) proteins induce post-mitotic terminally differentiated Sertoli cells to re-enter the cell cycle and proliferate. Biology of Reproduction 72:1205-1217.

Kezele PR, Ague J, Nilsson EE and MK Skinner (2005) Alterations in the ovarian transcriptome during primordial follicle assembly and development. Biology of Reproduction 72:241-255.

Cupp, A.S. and Skinner, M.K. (2005) Embryonic Sertoli cell differentiation. In: Sertoli Cell Biology eds. M.D. Griswold and M.K. Skinner, Elsevier -Academic Press, San Diego, CA, pp. 43-70.

Skinner, M.K. (2005) Sertoli cell secreted regulatory factors. In: Sertoli Cell Biology eds. M.D. Griswold and M.K. Skinner, Elsevier -Academic Press, San Diego, CA, pp. 107-120.

Chaudhary, J. and Skinner, M.K. (2005) Transcription factors in Sertoli cells. In: Sertoli Cell Biology eds. M.D. Griswold and M.K. Skinner, Elsevier -Academic Press, San Diego, CA, pp. 251-280.

Skinner, M.K. (2005) Sertoli Cell-Somatic Cell Interactions. In: Sertoli Cell Biology eds. M.D. Griswold and M.K. Skinner, Elsevier -Academic Press, San Diego, CA, pp. 317-328.

Small CL, Shima JE, Uzumcu M, Skinner MK and MD Griswold (2005) Profiling gene expression during the differentiation and development of the murine embryonic gonad. Biology of Reproduction 72:492-501.

Ojeda S and MK Skinner (2005) Puberty in the rat. In Encyclopedia of Reproduction, eds. Knobil & Neil, Elsevier – Academic Press, San Diego, CA.

2004

Chaudhary, J., Sadler-Riggleman, I and Skinner, M.K. (2004) Identification of a novel Sertoli cell gene product SERT that influences follicle stimulating hormone actions. Gene324:79-88.

Nilsson EE and MK Skinner (2004) Kit ligand and basic fibroblast growth factor interactions in the induction of ovarian primordial to primary follicle transition. Molecular and Cellular Endocrinology 214:19-25.

Saxlund MA, Sadler-Riggleman I, and MK Skinner (2004) Role of basic helix-loop-helix (bHLH) and CREB transcription factors in the regulation of Sertoli cell androgen-binding protein expression. Molecular Reproduction and Development 68:269-278.

Uzumcu M, Suzuki H, and MK Skinner (2004) Effect of the anti-androgenic endocrine disruptor vinclozolin on embryonic testis cord formation and postnatal testis development and function. Reproductive Toxicology 18:765-774.

2003

Skinner MK (2003) Cell-Cell Signaling in the Testis and Ovary. In: Handbook of Cell Signaling (Ralph A Bradshaw and Edward Dennis, eds.) Academic Press/Elsevier Science Publishing. Vol 3, chapter 342, pp 531-534.

Nilsson EE, Doraiswamy V, and MK Skinner (2003) Transforming Growth Factor-Beta (TGFb1, TGFb2 and TGFb3) expression during bovine ovarian antral follicle development. Molecular Reproduction and Development 66:237-246.

Kezele P and MK Skinner (2003) Regulation of ovarian primordial follicle assembly and development by estrogen and progesterone: endocrine model of follicle assembly. Endocrinology 144:3329-3337.

Cupp, A.S., Uzumcu, M., Suzuki, H., Dirks, K., Phillips, B., and MK Skinner (2003) Effect of transient embryonic in vivo exposure to the endocrine disruptor methoxychlor on embryonic and postnatal testis development. Journal of Andrology 24(5): 736-745.

Cupp AS, Uzumcu, M, and MK Skinner (2003) Chemotactic role of neurotropin 3 in the embryonic testis that facilitates male sex determination. Biology of Reproduction 68:2033-2037.

Nilsson EE and MK Skinner (2003) Bone morphogenetic protein-4 acts as an ovarian follicle survival factor and promote primordial follicle development. Biology of Reproduction 69:1265-1272.

2002

Nilsson, E, Westfall, S., McDonald, C,  I, Lisen, T, Sadler-Riggleman, and MK Skinner (2002) An in vivo mouse reproter gene (human seccreted alkaline phosphatase) model to monitor ovarian tumor growth and response to therapeutics. Cancer Chemo & Pharmacology 49:93-100.

Chaudhary, J. and Skinner, M.K. (2002) Identification of a novel Sertoli cell specific gene with a zinc finger domain, that is important for FSH activation of testicular Sertoli cells. Endocrinology 143:426-435.

Nilsson, E., Kezele, P. and Skinner, M.K. (2002) Leukemia inhibitory factor (LIF) promotes the primordial to primary follicle transition in rat ovaries. Molecular and Cellular Endocrinology 188:65-73.

Uzumcu M, Dirks K. and Skinner, M.K. (2002) Inhibition of platelet-derived growth factor actions in the embryonic testis influences normal cord development and morphology. Biology of Reproduction 66:745-753.

Cupp A, Tessarrolo L. and Skinner, M.K. (2002) Testis development phenotypes in neurotropin receptor trkA and trkC null mutations: role in seminiferous cord formation and germ cell survival. Biology of Reproduction 66:1838-1845.

Kezele PR, Nilsson E, and Skinner, M.K. (2002) Insulin but not insulin-like grwoth factor-1 promotes the prinmordial to primary folicle transition. Molecular and Cellular Endocrinology. 192:37-43.

Nilsson E and Skinner, M.K. (2002) Growth and differentiation factor-9 stimulates the progression of primary but not primordial ovarian follicle development. Biology of Reproduction 67:1018-1024.

Kezele P, Nilsson E, and Skinner, MK (2002) Cell-cell interactions in primordial follicle asembly and development. Frontiers in Bioscience 7:1990-1996.

Uzumcu M, Westfall S, Dirks K and MK Skinner (2002) Embryonic Testis Cord formation and mesonephric cell migration requires the phosphotidylinositol 3-kinase signaling pathway. Biology of Reproduction 67:1927-1935.

Devine PJ, Sipes EG, Skinner, MK and P. Hoyer (2002) Characterization of a rat in vitro ovarian culture system to study the ovarian toxicant 4-vinylcyclohexene diepoxide. Toxicology and Applied Pharmacology 184:107-115.

Nilsson EE and MK Skinner (2002) Role of transforming growth factor beta in ovarian surface epithelium biology and ovarian cancer. Reproductive Bio-Medicine Online 5(3):254-258.

2001

Nilsson E., Parrott, J. and Skinner M.K. (2001) Basic fibroblast growth factor induces primordial follicle development and initiates folliculogenesis. Molec. & Cellular Endocrinology 175:123-130.

Nilsson E. and Skinner MK (2001) Cellular interactions that control primordial follicle development and folliculogenesis. Journal Society Gynecologic Investigation 8 Supplemental: S17-S20.

Nilsson, E., Doraiswamy V., Parrott, J.A., and Skinner, M.K. (2001) Expression and action of transforming growth factor beta (TGFb1, TGFb2, TGFb3) in normal ovarian surface epithelium and implications for human ovarian cancer. Molecular and Cellular Endocrinology 182:145-155.

Parrott JA, Nilsson, E. Mosher R., Magrane G., Albertson D., Pinkel D., Gray JW, and Skinner M.K. (2001) Stromal-epithelial interactions in the progression of ovarian cancer: Influence and source of tumor stromal cells. Molecular and Cellular Endocrinology 175:29-39.

Cupp A.S., and Skinner, M.K. (2001) Actions of the endocrine disruptor methoxychlor and its estrogenic metabolite on in vitro embryonic rat seminiferous cord formation and perinatal testis growth. Repro. Tox. 15:317-326.

Cupp, A.S. and Skinner, M.K. (2001) Expression, action, and regulation of transforming growth factor alpha and epidermal growth factor receptor during embryonic and perinatal rat testis development. Journal of Andrology 22:1019-1029.

Chaudhary, J., Johnson, J., Kim, G., and Skinner, M.K. (2001) Hormonal regulation and differential actions of the helix-loop-helix transcriptional inhibitors of differentiation (Id1, Id2, Id3 and Id4) in Sertoli cells. Endocrinology 142:1727-1736.

Chaudhary, J. and Skinner, M.K. (2001) Role of transcriptional co-activator CBP/p300 in linking basic helix-loop-helix and CREB responses for follicle stimulating hormone mediated activation of the transferrin promoter in Sertoli cells. Biology of Reproduction 65:568-574.

Parrott JA, Doraiswamy V., Kim G., Mosher R, and Skinner M.K. (2001) Expression and actions of both the follicle stimulating hormone receptor and the leutinizing hormone receptor in normal ovarian surface epithelium and ovarian cancer. Molecular and Cellular Endocrinology 167:77-87.

2000

Parrott, J.A., and Skinner, M.K. (2000) Kit-ligand actions on ovarian stromal cells: Effects on theca cell recruitment and steroid production. Molecular Reproduction and Development 55:55-64.

Levine, E., Cupp A.S., and Skinner, M.K. (2000) Role of neurotropins in rat embryonic testis morphogenesis (cord formation). Biology of Reproduction 62:132-142.

Chaudhary, J., and Skinner, M.K. (2000) Characterization of a novel transcript of 14-3-3 theta in Sertoli cells. Journal of Andrology 21:730-738.

Levine, E., Cupp, A.S., Miyashiro, L., and Skinner, M.K. (2000) Role of transforming growth factor-alpha and the epidermal growth factor receptor in embryonic rat testis development. Biology of Reproduction. Biology of Reproduction 62:477-490

Parrott, J.A., and Skinner M.K. (2000) Expression and action of hepatocyte growth factor in human and bovine normal ovarian surface epithelium and ovarian cancer. Biology of Reproduction 62:491-50.

Parrott, J.A., Kim, G., and Skinner M.K. (2000) Expression and action of kit ligand/stem cell factor in normal human and bovine ovarian surface epithelium and ovarian cancer. Biology of Reproduction 62:1600-1609

Parrott, J., Mosher, R., Kim, G., and Skinner M.K. (2000) Autocrine interactions of keratinocyte growth factor, hepatocyte growth factor, and kit-ligand in the regulation of normal ovarian surface epithelial cells. Endocrinology 141:2532-2539

Doraiswamy, V., Parrott, J., and Skinner, M.K. (2000) Expression and action of transforming growth factor alpha in normal ovarian surface epithelium and ovarian cancer. Biology of Reproduction 63:789-796

Parrott, JA, Kim, G, Mosher, R, and Skinner, M.K. (2000) Expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium and ovarian cancer. Molec & Cellular Endocrinology 167:77-87

Chaudhary, J., Mosher, R., Kim, G., and Skinner M.K. (2000) Role of winged helix transcription factor (WIN) in the regulation of Sertoli cell differentiated functions: WIN acts as an early event gene for follicle stimulating hormone. Endocrinology 141:2758-2766

Cupp AS, Kim G, and Skinner M.K. (2000) Expression and action of neurotropin-3 and nerve growth factor in embryonic and early postnatal rat testis development. Biology of Reproduction 63:1617-28

Dissen, G.A., Parrott, J.,Skinner, M.K., Hill, D.F., Costa, M.E., and Ojeda, S. (2000) Direct effects of nerve growth factor on theca cells from antral ovarian follicles. Endocrinology 141:4736-50

1999


Chaudhary, J. and Skinner, M.K.: (1998) The basic helix-loop-helix E2A gene product E47, but not E12, is present in differentiating Sertoli cells. Molecular Reproduction and Development 52:1-8.

Parrott, J.A., and Skinner, M.K. (1999) Developmental and hormonal regulation of keratinocyte growth factor (KGF) expression and action the ovarian follicle. Endocrinology 139:228-235.

Chaudhary, J., and Skinner, M.K. (1999) Basic helix-loop-helix proteins can act at the E-box within the serum response element (SRE) of the c-fos promoter to directly influence promoter activation in Sertoli cells. Molecular Endocrinology 13:774-786.

Parrott, J. and Skinner, M.K. (1999) Kit-ligand/stem cell factor induces primordial follicle development and initiates folliculogenesis. Endocrinology 140(9):4262-4271.

Cupp, A.S. Kim, G., and Skinner, M.K. (1999) Expression and action of transforming growth factor beta (TGFb1, TGFb2, and TGFb3) during embryonic rat testis development. Biology of Reproduction 60:1304-1313.

Chaudhary, J. and Skinner, M.K. (1999) Expression of the basic helix-loop-helix protein REB-alpha in rat testicular Sertoli cells. Biology of Reproduction 60:1244-1250.

Cupp, A.S., Dufour, J., Kim, G., Kim, K.H., and Skinner M.K. (1999) Action of retinoids on embryonic and early postnatal testis development. Endocrinology 140:2343-2352.

McCarrey, J.R., O’Brian, D.A., and Skinner, M.K. (1999) Construction and preliminary characterization of a series of mouse and rat testis cDNA libraries. Journal of Andrology 20:635-639.

Lu Q, Gore M, Zhang Q, Camenisch T, Boast S, Casagranda F, Lai C, Skinner M.K., R Klein, Matsushima GK, Earp HS, Goff SP, Lemke G. (1999) Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398:723-8.

Chaudhary, J, and Skinner, MK (1999) E-box and cyclic adenosine monophosphate response elements are both required for follicle-stimulating hormone-induced transferrin promoter activation in Sertoli cells. Endocrinology 140:1262-71

Parrott, J. and Skinner, M.K. (1999) Gonadogenesis, female. In: Encyclopedia of Reproduction, eds Knobil, Academic Press NY. Vol 2: pp 61-69.

1998

Itoh, N., Patel, U., Cupp, A.S., and Skinner, M.K. (1998) Developmental and hormonal regulation of transforming growth factor beta (TGF-b1, 2, and 3) gene expression in isolated prostatic epithelial and stromal cells. Endocrinology 139: 1378-1388.

Itoh N., and Skinner, M.K. (1998) Developmental and hormonal regulation of transforming growth factor alpha (TGF-a) and epidermal growth factor receptor (EGFR) gene expression in isolated prostatic epithelial and stromal cells. Endocrinology 139:1369-1377.

Ross AJ, Waymire KG, Moss JE, Parlow AF, Skinner M.K., Russell LD, MacGregor GR: (1998) Testicular degeneration in Bcl-w deficient mice. Nature Genetics 18:251-256.

Parrott, J.A., and Skinner, M.K. (1998) Developmental and hormonal regulation of hepatocyte growth factor (HGF) expression and action in the ovarian follicle. Biology of Reproduction. 59:553-560.

Chaudhary, J. and Skinner, M.K. (1998) Comparative sequence analysis of the mouse and human transferrin promoters: hormonal regulation of the transferrin promoter in Sertoli cells. Molecular Reproduction and Development 50:273-283.

Gubbay, J., Doyle, J.P., Skinner, M.K., and Heintz, N. (1998) Changing patterns of gene expression identify multiple steps during regression of rat prostate in vivo. Endocrinology 139:2935-2943.

Parrott, J. and Skinner, M.K.: (1998) Theca cell - granulosa cell interactions involve a potitive feedback loop between keratinocyte growth factor, hepatocyte growth factor, and kit-ligand during ovarian follicular development. Endocrinology 139:2240-2245.

1997

Chaudhary, J., Cupp, A. and Skinner, M.K. (1997) Role of basic helix-loop-helix transcription factors in Sertoli cell differentiation: Identification of an E-box response element in the transferrin promoter. Endocrinology 138:667-675.

Parrott, J.A., and Skinner, M.K. (1997) Direct actions of kit-ligand on thecal cell growth and differentiation during follicle development. Endocrinology 138:3819-3827.

1996

Skinner, M.K. (1996) Cell-cell interactions that control spermatogenesis and oocyte maturation. In: Sexual differentiation and maturation, ed. Hibi I. and Tanaka T., Ares Serono 17:155-165.

Chaudhary, J., Whaley, Cupp, A., P. and Skinner, M.K. (1996) Transcriptional regulation of Sertoli cell differentiation by follicle stimulating hormone at the level of the cfos and transferrin promoters. Biology of Reproduction 54:692-699.

Ojeda, S.R., Mayerhofer, A., Dissen, G.A., Hill, D.F., Smith, G.D., Wolf, D.P., Dees, W.L. and Skinner, M.K. (1996) Ovarian development is influenced by a neuroendocrinotrophic regulatory complex. Elsevner Science, Excerta Medica Congress Series 1106.

Mayerhofer, A., Dissen, G., Parrott, J., Hill, D., Mayerhofer, D., Garfield, R., Costa, M., Skinner, M.K. and Ojeda, S. (1996) Involvement of nerve growth factor in the ovulatory cascade: trk A receptor activation inhibits gap-junctional communication between theca cells. Endocrinology 137:5662-5670.

1995

Chaudhary, J. and Skinner, M.K (1995) Transcriptional regulation of Sertoli cell differentiation (transferin promoter activation) during testicular development. Developmental Genetics 16:114-118.

Whaley, P., Chaudhary, J. and Skinner M.K. (1995) Role of specific response elements of the fos promoter and involvement of intermediate transcriptional factor(s) in the induction of Sertoli cell differentiation (transferrin promoter activation) by the testicular paracrine factor PModS. Endocrinology 136:3046-3053.

1994

Skinner, M.K. and Parrott J.P. (1994) Growth factor mediated cell-cell interactions in the ovary. In: Cellular and Molecular Mechanisms in Female Reproduction, ed. J.K. Findlay, Academic Press, pp. 67-81.

Norton, J.N., Vigne, J-L and Skinner, M.K. (1994) Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: Analysis of common signal transduction pathways. Endocrinology 134:149-157.

Mullaney, B.P., Rosselli, M. and Skinner, M.K. (1994) Developmental regulation of Sertoli cell lactate production by hormones and the testicular paracrine factor PModS. Molecular and Cellular Endocrinology 104:67-73.

Parrott, J., Vigne, J-L. and Skinner, M.K. (1994) Mesenchymal-epithelial cell interactions in the ovarian follicle involve keratinocyte and hapatocyte growth factor (KGF and HGF) production by theca cells and actions on granulosa cells. Endocrinology 135:569-575.

Vigne, J.L., Halburnt, L.L. and Skinner, M.K. (1994) Characterization of bovine ovarian surface epithelium (OSE) and stromal cells: identification of secreted proteins. Biology of Reproduction 51:1213-1221.

1993

Skinner, M.K. (1993) Secretion of growth factors and other regulatory agents by Sertoli cells. In: The Sertoli Cell, eds. M.D. Griswold and L.D. Russell, Cache River Press, Clearwater, FL, pp. 237-248.

Skinner, M.K. (1993) Sertoli cell-peritubular myoid cell interactions. In: The Sertoli Cell, eds. M.D. Griswold and L.D. Russell, Cache River Press, Clearwater, FL, pp. 477-484.

Mullaney, B.P. and Skinner, M.K. (1993) Transforming growth factor-beta (TGFß1, ß2 and ß3) gene expression and action during pubertal development of the seminiferous tubule: potential role in the induction of spermatogenesis. Molecular Endocrinology 7:67-76.

Parrott, J., Whaley, P and Skinner, M.K. (1993) Extra-Hapatic expression of fibrinogen by granulosa cells: Potential role in ovulation. Endocrinology 133:1645-1649.

1992

Rosselli, M. and Skinner, M.K. (1992) Developmental regulation of Sertoli cell aromatase activity and plasminogen activator production by hormones and the testicular paracrine factor, P-Mod-S. Biol. Reprod. 46:586-594.

Risbridger, G.P. and Skinner, M.K. (1992) Evaluation of the effects of peritubular cell secretions and the testicular paracrine factor PModS on Leydig cell inhibin production and steroidogenesis. Int. J. Andrology 15:73-83.

Skinner, M.K. (1992) Growth factors in gonadal development. J. Animal Science 70: 30-41.

Norton, J.N. and Skinner, M.K. (1992) Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: potential role of immediate-early genes. Molecular Endocrinology 6: 2018-2026.

Mullaney, B.P. and Skinner, M.K. (1992) Transforming growth factor-alpha and epidermal growth factor receptor expression and action during pubertal development of the seminiferous tubule. Molecular Endocrinology 6: 2103-2113.

Mullaney, B.P. and Skinner, M.K. (1992) Basic fibroblast growth factor (bFGF) gene expression and protein production during pubertal development of the seminiferous tubule; Follicle stimulating hormone induced Sertoli cell bFGF expression. Endocrinology 131: 2928-2934.

Skinner, M.K. (1992) Nonsteroidal regulation of testicular function. In: Development and Function of the Reproductive Organs, ed. S. Hillier, Serono Symposia Series, 94: 139-144.

1991

Skinner, M.K. (1991) Cell-cell interactions in the testis. Endocrine Reviews 12:45-77.

Mullaney, B.P. and Skinner, M.K. (1991) Growth factor regulation of testicular function. In: Growth Factors in Reproduction, ed. Schomberg, D., Serono Symposia Series, Springer-Verlag, NY, pp. 55-62.

Skinner, M.K., Norton, J.N., Mullaney, B.P., Rosselli, M., Whaley, P.A. and Anthony, C.T. (1991) Cell-cell interactions and the regulation of testis function. Ann. N.Y. Acad. Sci. 637:354-363.

Anthony, C.T., Rosselli, M. and Skinner, M.K. (1991) Actions of the testicular paracrine factor, P-Mod-S on Sertoli cell transferrin secretion during pubertal development. Endocrinology 129:353-360.

Danzo, B., Parrott, J. and Skinner, M.K. (1991) Analysis of the steroid binding domain of rat androgen binding protein. Endocrinology 129:690-696.

Roberts, A.J. and Skinner, M.K. (1991) Transforming growth factors alpha and beta differentially regulate cell growth and steroidogenesis of bovine thecal cells during antral follicle development. Endocrinology 129:2041-2048.

Mullaney, B.P. and Skinner, M.K. (1991) Growth factors as mediators of testicular cell-cell interactions. Baillieres Clinical Endocrinology and Metabolism 5(4):771-790.

Norton, J.N., Anthony, C.T. and Skinner, M.K. (1991) Cell-cell interactions that influence FSH regulation of testis function. In: Follicle Stimulating Hormone, eds. Hunzicker-Dunn, M. and Schwartz, N.B., Serono Symposia Series, Springer-Verlag, N.Y., pp. 231-236.

Skinner MK, Norton JN, Mullaney BP, Rosselli M, Whaley PD, Anthony CT. (1991) Cell-cell interactions and the regulation of testis function. Ann N Y Acad Sci. 637:354-63. Review.

1990

Skinner, M.K. (1990) Mesenchymal (stromal)-epithelial cell interactions in the testis and ovary which regulate gonadal function. Reproduction, Fertility and Development 2:237-243.

Skinner, M.K. (1990) Cell-cell interactions in the testis which regulate gonadal function. In: Neuroendocrine Regulation of Reproduction, eds. Yen, S. and Vale, W., Serono Symposia, Norwell, MA, pp. 175-178.

Roberts, A.J. and Skinner, M.K. (1990) Mesenchymal-epithelial interactions in the ovary: estrogen induced theca cell steroidogenesis. Mol. Cell. Endocrinol. 72:1-5.

Roberts, A.J. and Skinner, M.K. (1990) Hormonal regulation of theca cell function during antral follicle development in bovine ovaries. Endocrinology 127:2907-2917.

Roberts, A.J. and Skinner, M.K. (1990) Estrogen regulation of theca cell steroidogenesis and differentiation: theca cell-granulosa cell interactions. Endocrinology 127;2918-2922.

Skinner, M.K., Mullaney, B.P., Norton, J.N. and Anthony, C.T. (1990) Peritubular cell-Sertoli cell interactions: role of P-Mod-S and transforming growth factors. In: Hormonal Communication Events in the Testis, eds. Isidori, A., Fabbri, A., and Dufau, M., Serono Symposia, 70:165-169.

1989

Skinner, M.K., Schlitz, S.M. and Anthony, C.T. (1989) Regulation of Sertoli cell differentiated function: testicular transferrin and androgen binding protein expression. Endocrinology 124:3015-3024.

Anthony, C.T. and Skinner, M.K. (1989) Cytochemical and biochemical characterization of testicular peritubular (Myoid) cells. Biol. Reprod. 40:811-823.

Tsutsumi, M., Skinner, M.K. and Sanders-Bush, E.: (1989) Transferrin gene expression and synthesis by cultured choroid plexus epithelial cells: regulation by Serotonin and cyclic 3',5'-adenosine monophosphate. J. Biol. Chem. 264:9626-9631.

Norton, J. and Skinner, M.K.: (1989) Regulation of Sertoli cell function and differentiation through the actions of a testicular paracrine factor, P-Mod-S. Endocrinology 124:2711-2719.

Skinner, M.K., Stallard, B., Anthony, C.T. and Griswold, M.D. (1989) Cellular localization of fibronectin gene expression in the seminiferous tubule. Mol. Cell. Endocrinol. 66:45-52.

Anthony, C.T., Kovacs, W.J. and Skinner, M.K. (1989) Analysis of the androgen receptor in isolated testicular cell types with a microassay that utilizes an affinity ligand. Endocrinology 125:2628-2635.

Skinner, M.K., McLachlan, R.I. and Bremner, W.J. (1989) Stimulation of Sertoli cell inhibin production by the testicular paracrine factor, PModS. Mol. Cell. Endocrinol. 66:239-249.

Shingleton, J.L., Skinner, M.K. and Ong, D.E. (1989) Characteristics of retinol accumulation from serum retinol-binding protein by cultured Sertoli cells. Biochemistry 28:9641-9647.

Shingleton, J.L., Skinner, M.K. and Ong, D.E. (1989) Retinol esterification in Sertoli cells by lecithin-retinol acyltransferase. Biochemistry 28:9647-9653.

Skinner, M.K., Takacs, K. and Coffey, R.J. (1989) Transforming growth factor-alpha gene expression and action in the seminiferous tubule: peritubular cell-Sertoli cell interactions. Endocrinology 124:845-854.

Kovacs, W., Turney, M. and Skinner, M.K. (1989) Biochemical characterization of the protein affinity labeled by dihydroxytestosterone 17ß bromoacetate: comparison with the human androgen receptor. Endocrinology 124:1270-1277.

Skinner, M.K. and Moses, H.L. (1989) Transforming growth factor-beta gene expression and action in the seminiferous tubule: peritubular cell-Sertoli cell interactions. Mol. Endocrinol. 3:625-634.

Anthony, C.T. and Skinner, M.K. (1989) Actions of an extracellular matrix on Sertoli cell morphology and function. Biol. Reprod. 40:691-702.

Skinner, M.K. (1989) Peritubular myoid cell-Sertoli cell interactions which regulate testis function and growth. Perspectives in Andrology 53:175-182.

Skinner, M.K. (1989) Transforming growth factor production and action in the ovarian follicle: Theca cell-granulosa cell interactions. In: Growth Factors and the Ovary, ed. Hirshfeld, A., Serono Symposia, Plenum Press, pp. 141-150.

1988

Lobb, D., Skinner, M.K. and Dorrington, J.H. (1988) Rat theca/interstitial cell cultures produce a mitogenic activity that promotes the growth of granulosa cells. Molec. Cell. Endocrinology 55:209-217.

Skinner, M.K., Fetterolf, P.M. and Anthony, C.T. (1988) Purification of a paracrine factor, P-Mod-S, produced by testicular peritubular cells that modulates Sertoli cell function. J. Biol. Chem. 263:2884-2890.

Skinner, M.K. and Osteen, K.G. (1988) Developmental and hormonal regulation of bovine granulosa cell function in the preovulatory follicle. Endocrinology 123:1668-1676.

Skinner, M.K. and Coffey, R.J. (1988) Regulation of ovarian cell growth through the local production of transforming growth factor-a by theca cells. Endocrinology 123:2632-2638.

Skinner, M.K. (1988) Peritubular myoid cell-Sertoli cell interactions. Excerpta Medica, International Congress Series 799, Vol. 2, pp. 1145-1150.

1987

Skinner, M.K., Keski-Oja, J., Osteen, K. and Moses, H.L. (1987) Ovarian theca cells produce transforming growth factor beta which can regulate granulosa cell growth and differentiation. Endocrinology 121:786-792.

Skinner, M.K., Dean, L., Karmally, K. and Fritz, I.B. (1987) Rete testis fluid (RTF) proteins; characterization of RTF albumin and serum albumin. Biol. Reprod. 37:135-146.

Skinner, M.K., Lobb, D. and Dorrington, J.H. (1987) Ovarian theca/interstitial cells produce an epidermal growth factor-like substance. Endocrinology 121:1892-1899.

Skinner, M.K. (1987) Cell-cell interactions in the testis. Ann. N.Y. Acad. Sci. 513:158-171.

Fetterolf, P.M. and Skinner, M.K. (1987) Sertoli cells produce vitamin binding proteins. Ann. N.Y. Acad. Sci. 513:480-481.

Anthony, C.T. and Skinner, M.K. (1987) Effect of extracellular matrix on the hormonal regulation of Sertoli cell function. Ann. N.Y. Acad. Sci. 513:413-414.

1986

Fritz, I.B., Skinner, M.K. and Tung, P.S. (1986) The nature of somatic cell interactions in the seminiferous tubule. In: Development and Function of the Reproductive Organs, eds., Eshkol, A., Echstein, B., Dekel, N., Peters, H. and Tsafriri, A., Christengraf, Rome Pub. ARES-SERONO, pp. 185-202.

Skinner, M.K. and Fritz, I.B. (1986) Identification of a non mitogenic paracrine factor involved in mesenchymal-epithelial cell interactions between testicular peritubular cells and Sertoli cells. Molec. Cell. Endocrinol. 44:85-97.

Delovitch, T.L., Phillips, M.L., Naquet, P., Yip, C.C., Lin, J. and Skinner, M.K. (1986) Studies on the mechanism of processing and presentation of insulin by antigen presenting cells. In: Mediators of Immune Recognition and Immunotherapy, eds. Singhal, K. and Delovitch, T., Elsevier Publ., pp. 15-30.

Dorrington, J.H. and Skinner, M.K. (1986) Cytodifferentation of granulosa cells induced by gonadotropin releasing hormone (GnRH) promotes fibronectin secretion. Endocrinology 118:2065-2071.

1985

Skinner, M.K. and Fritz, I.B. (1985) Androgen stimulation of Sertoli cell function is enhanced by peritubular cells. Molec. Cell. Endocrinol. 40:115-122.

Skinner, M.K., Tung, P.S. and Fritz, I.B. (1985) Cooperativity between Sertoli cells and testicular peritubular cells in the production and deposition of extracellular matrix components. J. Cell Biol. 100:1941-1947.

Skinner, M.K. and Fritz, I.B. (1985) Testicular peritubular cells secrete a protein under androgen control that modulates Sertoli cell functions. Proc. Natl. Acad. Sci. USA 82:114-118.

Skinner, M.K., McKeracher H.L. and Dorrington, J.H. (1985) Fibronectin as a marker of granulosa cell cytodifferentiation. Endocrinology 117:886-892.

Skinner, M.K. and Fritz, I.B. (1985) Structural characterization of proteoglycans produced by testicular peritubular cells and Sertoli cells. J. Biol. Chem. 260:11874-11883.

1984

Skinner, M.K. and Griswold, M.D. (1984) Purification and characterization of testicular transferrin secreted by rat Sertoli cells. Biochem. J. 218:313-320.

Sylvester, S., Skinner, M.K. and Griswold, M.D. (1984) A sulfated glycoprotein synthesized by Sertoli cells and epididymal cells is a component of the sperm membrane. Biol. Reprod. 31:1087-1101.

Tung, P.S., Skinner, M.K. and Fritz, I.B. (1984) Fibronectin synthesis is a marker for peritubular cell contaminants in Sertoli cell-enriched cultures. Biol. Reprod. 30:199-211.

Tung, P.S., Skinner, M.K. and Fritz, I.B. (1984) Cooperativity between Sertoli cells and peritubular myoid cells in the formation of basal lamina in the seminiferous tubule. Ann. N.Y. Acad. Sci. 438:435-446.

Griswold, M.D., Huggenvik, J., Skinner, M.K. and Sylvester, S. (1984) The interaction of Sertoli cell glycoproteins with germinal cells in the testis. In: Endocrinology, eds. Labrie, F. and Proulx, L., Excerpta Medica N.Y., International Congress Series 655, pp. 619-622.

Dorrington, J., McKeracher, H., Garzo, G. and Skinner, M.K. (1984) Granulosa cell-theca cell interactions during follicular development. In: Endocrinology, eds. Labrie, F. and Proulx, L., Excerpta Medica N.Y., International Congress Series 655, pp. 807-810.

Skinner, M.K. and Dorrington, J.H. (1984) Control of fibronectin synthesis by rat granulosa cells in culture. Endocrinology 115:2029-2031.

1983

Skinner, M.K. and Griswold, M.D. (1983) Fluorographic detection of radioactivity in polyacrylamide gels with 2,5-diphenyloxazole in acetic acid and its comparison with existing procedure. Biochem. J. 209:281-284.

Skinner, M.K. and Griswold, M.D. (1983) Sertoli cells secrete a ceruloplasmin-like protein. Biol. Reprod. 28:1225-1229.

Skinner, M.K. and Griswold, M.D. (1983) Multiplication stimulating activity (MSA) can substitute for insulin to stimulate the secretion of testicular transferrin by cultured Sertoli cells. Cell Biol. International Reports 7(6):441-446.

1982

Skinner, M.K. and Griswold, M.D. (1982) Secretion of testicular transferrin by cultured Sertoli cells is regulated by hormones and retinoids. Biol. Reprod. 27:211-221.

Kissinger, C., Skinner, M.D. and Griswold, M.D. (1982) Analysis of Sertoli cell-secreted proteins by two-dimensional gel electrophoresis. Biol. Reprod. 27:233-240.

1980

Skinner, M.K. and Griswold, M.D. (1980) Sertoli cells synthesize and secrete transferrin-like protein. J. Biol. Chem. 255(20):9523-9525.

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